Chinese herbal compound database screening, target prediction, PPI network construction, pathway enrichment and in vitro cellular validation were integrated for analysis.
Key Findings
Signature bioactive compounds with anti-hepatoma potential from multiple ethnic medicinal plants were identified.
Core signaling pathways governing tumor proliferation and apoptosis synergistically modulated by bioactive ingredients were characterized.
Preliminary experimental data were provided to support the development of candidate adjuvant anti-hepatocellular carcinoma drugs derived from ethnic medicinal resources.
The corresponding article Systems pharmacology approaches decipher the anti-cancer efficacy of ethnopharmacological agents in hepatocellular carcinoma was published in Scientific Reports (IF: 4.6)