Background: Tumor microenvironment heterogeneity is a major cause of therapy resistance.

Key Findings:

  1. Identified 5 novel macrophage subtypes with distinct functional programs
  2. Discovered a M2-like subtype associated with poor prognosis (HR=2.3, p<0.001)
  3. Mapped cell-cell communication networks revealing TGF-β as a key signaling axis
  4. Validated in an independent cohort of 200 patients

Publication: Under review at Cancer Cell.