CCK-8, wound-healing and Transwell assays were used to detect cancer cell proliferation and migration. Transcriptome sequencing was applied to screen downstream target genes regulated by cordycepin.
Key Findings:
Cordycepin at proper doses significantly blocks cell cycle progression and inhibits in vitro proliferation of lung cancer cells.
Cordycepin downregulates the expression of key epithelial-mesenchymal transition genes and weakens the invasion and migration capacity of tumor cells.
Cordycepin has potential medicinal development value for anti-lung cancer therapy.
Research Progress
Mechanism of cordycepin inhibiting proliferation and migration of non-small cell lung cancer cells
👤 Li Rong, Wang Lin, Zhao Qian (Corresponding author: Anping Liu)
📅 二月 20, 2023
📍 Mycosystema
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Summary:In vitro cell experiments were carried out to explore the inhibitory effects of cordycepin on proliferation, invasion and migration of non-small cell lung cancer cells and its molecular mechanism regulating cell cycle and epithelial-mesenchymal transition.
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