High-quality genome assembly of the AB strain was generated and compared with the published Tuebingen reference genome for genome-wide structural variant analysis.
Key Findings:
Substantial structural variations and sequence divergence exist between the reference genomes of these two mainstream zebrafish laboratory strains.
Genomic signatures of genetic differentiation among zebrafish subpopulations caused by long-term laboratory domestication were revealed.
This work reminds researchers that genomic differences between strains may interfere with experimental repeatability in developmental and pharmacological studies.