Cross-species analysis covering over 400 taxa deciphers the IL-1 superfamily: disease association mechanisms and mining of potential therapeutic targets

Over 400 metazoan genomes were integrated to construct phylogenetic trees, combined with target conservation analysis, pathway enrichment and disease association dissection.
Key Findings
The origin, lineage-specific expansion, structural and functional divergence patterns of the IL-1 superfamily were delineated.
Multiple evolutionarily conserved core members were screened as precise targeting loci for inflammatory diseases.
Theoretical support for novel targeted drug development against IL-1 pathway-related immune disorders was provided from an evolutionary perspective.
The corresponding article IL-1 Superfamily Across 400+ Species: Therapeutic Targets and Disease Implications was published in Biology (IF: 4.3)